In vivo, no tumors were detected in rats from the control group, while 11 rats out of 12 (91.66%) developed mammary tumors in the DMBA-exposed group receiving only the vehicle. The Acacia seyal extract exhibited CC 50 of 100 in MCF-7 cells after 24 h. Incidence, burden, volume, and histological analysis of mammary tumors were measured. seyal stem barks was evaluated on 7,12-dimethylbenz(a)anthracene- (DMBA-) induced breast cancer rat model. Further, the protective effect of the hydroethanolic extract of A. seyal extract was evaluated using resazurin reduction assay in 9 cell lines. seyal hydroethanolic extract on breast cancer. ![]() ![]() The present study was designed to evaluate the in vitro and in vivo antitumor effects of A.
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